ea0056gp170 | Paediatrics, Developmental ' Female Reproduction | ECE2018
Popova Polina
, Vasilieva Lyudmila
, Tkachuck Alexandra
, Puzanov Maxim
, Golovkin Alexey
, Bolotko Yana
, Pustozerov Evgenii
, Zazerskaya Irina
, Dmitrieva Renata
, Grineva Elena
Background: Gestational diabetes mellitus (GDM) is known to predispose offspring to metabolic diseases. However, the underlying mechanisms has not been thoroughly studied yet. The glucocorticoid receptor gene or nuclear receptor sub-family 3, group C, member 1 (NR3C1) may predispose to type 2 diabetes mellitus, metabolic syndrome and depression. NR3C1 gene showed significantly decreased methylation levels in cord blood and placenta from GDM women compared wit...